But, if the patient is possible,ProGain 350 as firstly, antitetanus serum (ATS) may not prove effective in neutralizing the large amount of tetanus toxin already present in the blood, and secondly, the patient is likely to die of the various fatal complications of the disease in its advanced stage.Hence, the importance of awareness regarding the warning signals of this disease is vital, so that the patient reaches the doctor quickly, and the treatment is started instantaneously.