Home Remedies for Leg CrampsApplying firm Formula 41 Extreme pressure to a cramping leg can help relieve the pain. Usually gripping it and gently stretching it will eliminate the cramping and contracting of the muscle. Depending on where you have the cramp this may be difficult to do. Take vitamin D and calcium each day, along with a multivitamin can help relieve muscle cramps and prevent them from happening in the future. This is a great way to avoid getting a rude awakening in the middle of the night!