You scrub your hands more than any other part of your body, so you should moisturize them throughout your day. Also, use a night cream once a week or so to give your hands some extra moisture.Luna Skin Serum Using a daily moisturizer that contains sunscreen is one of your best defenses in the battle against wrinkles. Sunlight can really harm your face and cause premature wrinkles. To help protect your face, apply a moisturizer that contains sunscreen.