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Can explain folding with realistic stiffness MAX SYNAPSE ratios, but disagrees with dissection experiments (Xu et al., 2010). Differential growth, a mechanism to release residual stresses by surface buckling (Ronan et al., 2014), agrees with dissection experiments, but requires unrealistic stiffness ratios (Richman et al., 1975). Combining both mechanisms has motivated theories of stretch- and stress-driven growth, concepts that agree with both realistic stiffness ratios and maximum principal stress distributions (Bayly et al., 2013; Budday et al., 2014b). Figure 2. Organization of a fully developed brain. In white matter, myelinated axons allow for rapid nerve impulse conduction; intermediate oligodendrocytes connect and MAX SYNAPSE Reviews form several myelin sheaths. Fibrous astrocytes ensure supply of nutrients and synaptic processing. In gray matter, neurons form synapses with each other and with protoplasmic astrocytes. In both white and gray matter, microglial cells contribute to clearance of debris and synapse remodeli

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