Releaf Drops This 100% natural formula contains cannabinoids. In fact, that’s the main thing we love about the Releaf Ingredients. Cannabinoids work directly with your Endocannabinoid System (ECS). This system usually stops pain and stress on its own. For example, if you bang your arm on a desk, your ECS releases endocannabinoids to make that pain fade away. Or, if you’re stressed over a presentation, those endocannabinoids can help you relax when it’s over.